评估炎症性肠病与动脉样性心血管疾病风险之间的因果关系:单变和多变孟德尔随机化研究
Baike Liu1,2, Zijian Qin3, Zhaolun Cai1,2
1Gastric Cancer Center, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Biomedicines
|September 28, 2023
概括
这项研究发现,炎症性肠病 (IBD) 与冠状动脉疾病 (CAD) 或缺血性中风风险增加之间没有因果关系. 观察性研究可能受到混因素的影响,而不是直接的因果关系.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 心脏病学 心脏病学
背景情况:
- 观察性研究表明,包括克罗恩病 (CD) 和性结肠炎 (UC) 在内的炎症性肠病 (IBD) 与动脉样硬化心血管疾病 (ASCVD) 风险增加之间存在联系.
- 这种关联的因果关系尚不清楚,需要进一步调查.
研究的目的:
- 调查IBD,CD和UC对冠状动脉疾病 (CAD) 和缺血性中风风险的潜在因果影响.
- 使用两个样本的门德尔随机化 (MR) 方法来评估因果关系.
主要方法:
- 针对IBD,CD和UC的遗传工具是从欧洲人群的全基因组关联研究 (GWAS) 中确定的.
- 使用来自多个联盟 (CARDIoGRAMplusC4D,MEGASTROKE,FinnGen,英国生物银行) 的数据,采用了反变异加权 (IVW) 和多变量MR (MVMR) 方法.
主要成果:
- 门德尔随机分析显示,IBD (整体,CD或UC) 对CAD风险没有统计学上显著的因果作用.
- 同样,IBD (整体,CD或UC) 与缺血性中风风险之间也没有发现因果关系.
- 在IVW,元分析和MVMR方法中,结果一致.
结论:
- MR 分析不支持 IBD 与 CAD 或缺血性中风风险之间的因果关系.
- 与观察性研究的差异可能源于不受控制的混因素,例如IBD药物或检测偏差,这需要进一步研究.
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