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心力衰竭中的人类肠道微生物群:试图揭开一个新兴器官的面具
Ioannis Paraskevaidis1, Andrew Xanthopoulos2, Elias Tsougos1
16th Department of Cardiology, Hygeia Hospital, 15123 Athens, Greece.
Biomedicines
|September 28, 2023
概括
肠道微生物群影响心脏健康,影响心力衰竭 (HF) 的发展和进展. 改变生活方式和像益生菌这样的干预措施可以积极影响肠道微生物群,可能有利于患有HF的患者.
科学领域:
- 心脏病学 心脏病学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在维持肠道平衡和影响全身健康方面发挥着至关重要的作用.
- 食脂肪酸被肠道微生物群和肝酶代谢成三甲基胺N氧化物 (TMAO),这是与心血管疾病有关的化合物.
- 心力衰竭 (HF) 可以危及肠道屏障功能,导致微生物转移和全身炎症.
研究的目的:
- 审查肠道微生物群与心力衰竭之间的双向关系.
- 探索肠道微生物群影响HF发育和进展的机制.
- 讨论潜在的治疗策略,以肠道微生物群为目标,以对抗HF.
主要方法:
- 关于肠道微生物群和心力衰竭的现有研究的文献综述.
- 分析涉及肠道微生物群,饮食和心血管风险因素的代谢途径.
- 检查HF对肠道生理学和微生物组成的影响.
- 审查HF药物对肠道微生物群的影响,反之亦然.
主要成果:
- 肠道微生物群失调与增加的TMAO生产,动脉动脉生成和血栓事件有关.
- 由HF引起的肠道功能障碍有助于微生物的转移,导致轻度炎症.
- 肠道微生物群可以改变HF药物的疗效和药理动力学.
- 改变生活方式 (地中海饮食,运动) 和前/益生菌对高频率患者的肠道健康有潜在的益处.
结论:
- 肠道微生物群是心力衰竭的发病和进展的一个重要因素.
- 准肠道微生物群是一个有希望的治疗途径,用于管理心力衰竭.
- 需要进一步的研究来阐明复杂的相互作用,并开发有效的基于微生物群的干预措施,以改善心血管健康.
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