康复:脊髓损伤后的神经性骨损失
Giovanna E Leone1,2, Donald C Shields2, Azizul Haque1,2,3
1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.
Biomedicines
|September 28, 2023
概括
脊髓损伤 (SCI) 加快骨质疏松症和肉,增加骨折风险. 本综述探讨了与SCI相关的肌肉和骨质损失机制以及维护骨质的疗法.
科学领域:
- 整形外科 整形外科 整形外科
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 骨质疏松症和肉症是与年龄相关的疾病.
- 脊髓损伤 (SCI) 加剧肌肉和骨质损失由于神经性因素,不使用,和细胞变化.
- 在SCI后维持骨质量对于降低受影响个体骨折风险至关重要.
研究的目的:
- 审查SCI后肌肉和骨损失的病理生理学和危险因素.
- 讨论SCI中加速骨损失背后的机制.
- 探索神经性骨质损失的当前和未来治疗策略.
主要方法:
- 关于SCI相关的肌肉骨损失的最近研究的文献综述.
- 对病理生理机制和危险因素的分析.
- 药理和非药理治疗方法的综合.
主要成果:
- SCI导致迅速和严重的骨质疏松症和肉症.
- 神经性因素,肌肉骨不使用以及细胞事件对骨质损失有显著的贡献.
- 新兴疗法在减轻或逆转神经性骨质损失方面表现有前途.
结论:
- 了解SCI诱导的骨损失机制对于开发有效的干预措施至关重要.
- 药理和非药理疗法对于在SCI群体中保持骨健康至关重要.
- 对抗骨质疏松症和SCI后的肉症的新型治疗策略的进一步研究是有必要的.
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