益生菌菌株Bifidobacterium longum亚种的氧化应激反应 长 GT15 GT15 GT15 GT15 GT15 GT15 GT15 GT15 GT15 GT15 GT15 GT15 GT15 GT15
Olga V Averina1, Aleksey S Kovtun1, Dilara A Mavletova1
1Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia.
Foods (Basel, Switzerland)
|September 28, 2023
概括
这项研究揭示了Bifidobacterium longum GT15 GT15的存在.
科学领域:
- 微生物学 微生物学
- 我们的肠道微生物群.
- 益生菌 益生菌 益生菌
背景情况:
- 双杆菌在肠道微生物群中至关重要,具有已知的健康益处.
- 需要进一步调查Bifidobacterium的抗氧化潜力.
- 现有研究表明,Bifidobacterium菌株具有抗氧化能力.
研究的目的:
- 研究Bifidobacterium longum亚种中的氧化应激反应机制. 长 GT15.15 长 GT15.15 长 GT15.15 长 GT15.15 长
- 分析对氧化应激的多组反应 (转录组,蛋白组,代谢组).
- 识别关键的基因,蛋白质和参与抗氧化防御的途径.
主要方法:
- 在B. longum GT15的基因组测序.
- 转录组,蛋白组和代谢组分析.
- 将细菌培养暴露在过氧化和氧气中.
主要成果:
- 在B. longum GT15基因组中确定了16个与抗氧化剂相关的基因.
- 在压力下观察到11个抗氧化剂基因的转录增加了2倍以上.
- 检测到谷氨素和氨素的显著上调,表明氨素系统的关键作用.
- 发现蛋白质含量增加,这与应激反应,新陈代谢和运输有关.
- 代谢指纹检测显示,在受压力和不受压力的细胞之间有明显的区别.
结论:
- B. longum GT15具有强大的抗氧化防御系统.
- 这种依赖于硫素的系统是B. longum.um.中氧化还原恒温的核心.
- 了解氧化应激反应可以提高对B. longum在食品中的生存率的了解.
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