在MRI阴性中认知障碍:神经生理学和神经心理学的测量之间的关系
Vasileios Papaliagkas1, Chrysanthi Lokantidou-Argyraki2, Panayiotis Patrikelis2
1Department of Biomedical Sciences, School of Health Sciences, International Hellenic University, 57001 Thessaloniki, Greece.
Diagnostics (Basel, Switzerland)
|September 28, 2023
概括
认知障碍,包括记忆和注意力缺陷,在患者中很常见. 这项研究在MRI阴性患者中发现了延长的P300延迟和认知能力受损,表明过渡性认知障碍.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 认知科学 认知科学
背景情况:
- 经常导致认知障碍,特别是影响记忆,注意力和执行功能.
- 的认知缺陷往往取决于活动的位置.
- 了解这些认知变化对于患者管理至关重要.
研究的目的:
- 用神经生理学和神经心理学方法评估MRI阴性患者的认知功能.
- 为了调查EEG期间与形放电相关的过渡性认知障碍.
- 为了将认知表现与神经生理学标记者相关联.
主要方法:
- 招募了20名MRI阴性患者和10名年龄匹配的对照.
- 听觉事件相关潜力 (ERP) 和EpiTrack认知查工具进行了管理.
- 排除标准包括性病变;获得了知情同意.
主要成果:
- 与对照组相比,患者表现出延长的P300和慢波延迟 (p <0.05).
- 抗药物 (ASM) 负载和EpiTrack迷宫性能预测了P300延迟.
- 患者的记忆力,注意力和信息处理速度都有所下降.
结论:
- 核磁共振阴性与显著的认知障碍有关,包括记忆和注意力缺陷.
- 长时间的P300潜伏期作为中认知功能障碍的神经生理学标志物.
- 患者可能会出现过渡性认知障碍,与型活动相关.
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