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甲状腺癌幸存者的后期原发性癌症风险:全国性基于人口的研究
Min-Su Kim1, Sang Jun Lee2, Myeong Hoon Lee2
1Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University School of Medicine, CHA University, Seongnam 13496, Republic of Korea.
Diagnostics (Basel, Switzerland)
|September 28, 2023
概括
甲状腺癌幸存者患上后续原发性癌症 (SPCs) 的风险明显更高. 这种增加的风险在年轻患者和在最初的甲状腺癌5年内被诊断出来的患者中尤为明显.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 甲状腺癌幸存者往往有良好的预后和长寿命.
- 然而,这些幸存者面临着患上后续原发性癌症 (SPC) 的风险增加.
- 了解这种风险对于长期的患者管理至关重要.
研究的目的:
- 研究甲状腺癌患者的SPC风险和类型.
- 为了比较甲状腺癌幸存者的SPC发病率与没有甲状腺癌史的个人.
- 为了确定具有较高SPC风险的特定患者群体.
主要方法:
- 全国范围,以人口为基础,使用韩国国家医疗保险数据库 (2004-2019) 进行回顾性队列研究.
- 432,654名甲状腺癌患者与对照进行了1:1匹配.
- 考克斯比例危险模型用于估计SPC的危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 与对照组相比,甲状腺癌患者的SPC风险显著更高 (调整HR,1.62;95%CI,1.60-1.64).
- 在长达6.9年的随访中,18.2%的甲状腺癌患者和11.6%的对照人群开发了SPC.
- 甲状腺癌的风险在被诊断为甲状腺癌的年龄较小 (<40岁) 和诊断后5年内的患者中特别高.
结论:
- 患上甲状腺癌的幸存者面临着患上随后的原发性癌症的风险大幅增加.
- 医疗保健提供者应为甲状腺癌患者实施长期随访策略.
- 关于SPC风险的讨论是有必要的,特别是对于年轻的患者和诊断后5年内的患者.
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