肠道微生物群在慢性肝病的发展中:目前的状况
Josip Stojic1, Michał Kukla2,3, Ivica Grgurevic1,4,5
1Department of Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, 10000 Zagreb, Croatia.
Diagnostics (Basel, Switzerland)
|September 28, 2023
概括
改变的肠道微生物群 (失生症) 通过影响肠肝轴,导致慢性肝病 (CLD). 调节肠道微生物组为管理CLD提供了潜在的治疗策略.
科学领域:
- 胃肠病学和肝病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性肝病 (CLD) 是一个重大的全球健康挑战.
- 肠-肝轴促进肠道微生物群和肝脏之间的双向通信.
- 肠道失调与免疫失调,代谢变化和增加肠道透性有关,加剧肝损伤.
研究的目的:
- 审查当前关于健康和CLD中的肠道微生物组合的知识.
- 探索影响微生物组组成的因素及其对肝脏健康的影响.
- 分析肠道微生物组调制策略在管理CLD中的有效性.
主要方法:
- 对肠道微生物群和CLD研究的文献综述.
- 分析影响肠道微生物组组成的因素.
- 针对肠道微生物组的治疗干预措施的评估.
主要成果:
- 失生症是CLD的常见特征,无论病因如何.
- 改变的肠道微生物群有助于通过肠肝轴的肝炎和损伤.
- 药物治疗,营养,便微生物群移植,补充剂和益生菌在调节用于CLD治疗的微生物群方面显示出潜力.
结论:
- 肠道微生物组是CLD病变发生的关键因素.
- 通过微生物组调制准肠肝轴是一个有前途的治疗途径.
- 将肠肝相互作用的研究转化为临床实践可以提高CLD管理.
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