脂蛋白相关脂酶A2具有与人类指数相比的能力,可以区分心血管疾病风险:一项横截面研究
E N Adejumo1, J D Adefoluke1, N L Nwobi2
1Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Ogun State, Nigeria. Phone: +2347033689407.
West African journal of medicine
|September 28, 2023
概括
肥胖指数和脂蛋白相关脂酶A2 (Lp-PLA2) 有效预测尼日利亚大学工作人员心血管疾病 (CVD) 风险. 无论是Lp-PLA2和人体测量都显示出男性和女性心血管疾病风险的可比预测能力.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生化学
- 公共卫生 公共卫生
背景情况:
- 肥胖指数是心血管疾病 (CVD) 的潜在预测指标.
- 关于尼日利亚人群中CVD风险评估的Lp-PLA2和人体指数的比较数据有限.
研究的目的:
- 为了比较脂蛋白相关脂酶A2 (Lp-PLA2) 和心血管疾病 (CVD) 风险的人类指数的预测能力.
- 在尼日利亚西南部的看似健康的大学工作人员中评估这些预测因素.
主要方法:
- 在看似健康的大学工作人员身上进行了一项描述性的横截面研究.
- 测量包括人体测量 (BMI,WC,HC等). ),血压,Lp-PLA2,脂质概况,以及禁食血葡萄糖.
- 心血管疾病风险是由一般/腹部肥胖,糖尿病,脂质失调,高血压或吸烟定义的;ROC曲线分析了预测器性能.
主要成果:
- 75.7%的参与者有心血管疾病风险.
- 在患有心血管疾病风险的参与者中,Lp-PLA2和大多数人体指数显著更高 (p<0.05).
- 在男性中,Lp-PLA2显示出最高的AUC (0.886),紧随其后的是BMI和WC. 在女性中,腰与身高的比率 (WHtR) 的AUC最高 (0.995),其次是WC和BMI.
结论:
- 无论是Lp-PLA2和人体指数,都显示出显著的能力来区分心血管疾病风险.
- 在男性和女性参与者之间,Lp-PLA2和人类指数的预测能力是可比的.
- 研究结果支持使用这些指数来评估该人群中心血管疾病风险.
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