儿童的功能性腹痛障碍可能与食物不耐受/吸收不良有关
Wolfgang J Schnedl1,2, Michael Schenk3, Simon Michaelis4
1Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A-8036 Graz, Austria.
Children (Basel, Switzerland)
|September 28, 2023
概括
儿童的功能性腹痛障碍通常与食物不耐受有关. 这项研究发现,研究乳糖不耐症,组胺不耐症和果糖吸收不良可以确定患有FAPD的儿科患者的潜在原因.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
- 免疫学 免疫学 免疫学
背景情况:
- 功能性腹痛障碍 (FAPD) 在儿童中很常见,表现为慢性腹痛和改变肠道习惯.
- FAPDs的确切病理生理学尚不清楚,但存在与食物不耐受和吸收不良的潜在联系.
- 目前在儿科患者群体中针对FAPD的诊断方法需要进一步改进.
研究的目的:
- 调查被诊断患有FAPD的儿童中食物不耐受和吸收不良的流行情况.
- 评估一个个性化的诊断方法,用于识别儿科FAPD的特定食物不耐受.
- 建立FAPDs与乳糖不耐症,组胺不耐症和果糖吸收不良等疾病之间的联系.
主要方法:
- 在2017年至2022年期间调查的51名患有FAPD的儿科患者的回顾性分析.
- 使用了小肠活检,气呼吸试验 (用于乳糖和果糖吸收不良),血清二胺氧化酶 (DAO) 水平 (用于胰岛素不耐受),以及腹腔疾病抗体查.
- 包括针对*H. pylori*感染的IgA抗体检测.
主要成果:
- 所有51名儿童被诊断出至少有一种食物不耐受或吸收不良的情况.
- 患病率包括果糖吸收不良 (n=7),胰岛素不耐受 (n=8),乳糖不耐受 (n=8).
- 观察到明显的重叠,在70%的患者中发现了不耐受性的组合,包括三重组合.
结论:
- 儿童的功能性腹痛障碍经常与可识别的食物不耐受和吸收不良有关.
- 一个个性化的,多面的诊断策略有效地识别了儿科FAPDs这些潜在的条件.
- 在注册营养学家的指导下进行饮食修改,对于在诊断出食物不耐受症后管理FAPD至关重要.
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