怀孕和没有心血管风险的妊娠中脂质谱变化:对母亲和新生儿的后果
Simona-Alina Abu-Awwad1,2, Marius Craina2,3,4, Lioara Boscu1
1Doctoral School, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Children (Basel, Switzerland)
|September 28, 2023
概括
患有心血管风险的孕妇面临更高的新生儿不良结果风险,包括异常APGAR分数和死亡率. 这凸显了需要更好地评估和管理高风险怀孕的风险.
科学领域:
- 产科和妇科 产科和妇科
- 心脏病学 心脏病学
- 新生儿科学 新生儿科学
背景情况:
- 孕产妇心血管风险显著影响孕产妇和新生儿的健康.
- 要了解这些影响,需要比较怀孕妇女的脂质样本,包括有心血管风险和没有心血管风险的孕妇.
研究的目的:
- 为了比较怀孕妇女与没有心血管风险因素之间的脂质概况.
- 研究母亲心血管风险与新生儿结局之间的关联.
主要方法:
- 86名孕妇被分为两个组:健康的怀孕 (n=46) 和患有心血管风险因素的怀孕 (n=40).
- 数据包括母亲人口统计,病史,实验室测量 (脂质,hs-CRP) 和新生儿结局 (APGAR,异常,早产,死亡率,出生体重).
主要成果:
- 患有心血管风险因素的妇女在新生儿期的结果明显差,包括更高的异常APGAR评分,先天性异常,严重早产和新生儿死亡率.
- 在心血管风险组中观察到总胆固醇,LDL-C,ApoB,Lp(A),甘油三和hs-CRP的水平升高.
- 在高风险组中,出生体重和需要表面活性剂,类固醇和抗生素的显著差异被发现.
结论:
- 患有心血管风险因素的怀孕与新生儿不良后果的风险显著增加有关.
- 高风险怀孕中的不同脂质和炎症概况表明,病理生理学与不良结果的联系.
- 有效的风险分层和管理策略对于患有心血管风险的孕妇至关重要.
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