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在人类疾病中识别和分析性别偏差的微RNA

Bitao Zhong¹, Chunmei Cui¹, Qinghua Cui¹

¹Department of Biomedical Informatics, Center for Noncoding RNA Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, 38 Xueyuan Rd, Beijing 100191, China.

|September 28, 2023

概括

与男性相比,女性具有更高表达的,与更广泛的疾病相关的保存型微RNA (miRNAs). 这项研究在疾病中识别出性别偏差的miRNA,用于精准医学应用.

科学领域:

基因组学就是基因组学.
生物化学生物化学
医学科学医学科学医学科学

背景情况:

已知有显著的基于性别的生理和疾病差异.
关于微RNA (miRNA) 表达的性别差异的先前研究主要集中在健康个体或单一疾病上.
需要对跨疾病的性别偏差miRNA进行全面的分析.

研究的目的:

在各种疾病中识别和分析性别偏见的miRNA.
了解性别偏差miRNA表达在疾病发病过程中的影响.
探索精准医学中的潜在应用.

主要方法:

在疾病背景下利用miRNA表达数据集来识别男性和女性之间的性别偏差miRNA.
对已识别的性别偏差miRNA进行了生物信息学分析.
采用TAM 2.0工具进行miRNA集丰富分析,包括转录因子,功能和相关疾病.

主要成果:

在疾病中识别了具有性别偏差表达的miRNAs.
研究人员发现,与男性相比,女性表现出更多的保存,高度表达的miRNAs.
这些miRNA与更广泛的疾病谱系有关.

结论:

性别偏差miRNA表达在疾病中普遍存在.
女性中保存的,高度表达的miRNA数量较多,可能会导致性别特异性疾病模式.
这些发现支持精准医学中针对疾病管理的量身定制方法.

关键词:

生物信息分析分析生物信息分析这是一个微型RNA.性别偏见的表达方式.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...