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Updated: Jul 15, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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全外体测序揭示了原发性和匹配性复发性三阴性乳腺癌之间的高突变一致性

Jaspreet Kaur1, Darshan S Chandrashekar2, Zsuzsanna Varga3

  • 1Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

Genes
|September 28, 2023
PubMed
概括

对三阴性乳腺癌 (TNBC) 的基因组分析揭示了原发性和复发性瘤之间的相似遗传特征. 这表明TNBC的遗传构成在局部复发期间可能保持稳定,为治疗策略提供了洞察力.

关键词:
三重阴性乳腺癌是什么瘤突变负担的突变负担整体外基因组测序的测序

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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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