奥登托基性瘤和囊的干细胞表达特征:系统性审查和元分析
Eleni-Marina Kalogirou1, Georgios Lekakis2, Aristodimos Petroulias2
1Faculty of Health and Rehabilitation Sciences, Metropolitan College, 10672 Athens, Greece.
Genes
|September 28, 2023
概括
用SOX2等标记物识别的干细胞在瘤和囊中起作用. SOX2有效地区分了乳腺癌和乳腺瘤的乳腺癌和乳腺瘤.
科学领域:
- 口腔病理学 口腔病理学
- 干细胞生物学 干细胞生物学
- 在瘤学瘤学.
背景情况:
- 干细胞具有自我更新和可塑性特性,影响着臭虫病原性病变的发病和行为.
- 在牙致癌瘤和囊中研究干细胞标记物对于了解疾病机制至关重要.
研究的目的:
- 系统地审查干细胞标记物在瘤和囊中表达的表达.
- 分析干细胞标记物与这些病变的生物行为之间的关联.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Web of Science,CINHAL) 进行了全面的文献搜索.
- 包含了评估牙病变和对照组中干细胞标记物的原始研究.
- 使用乔安娜·布里格斯研究所的批判性评估工具评估了偏差风险,并在适当的情况下进行了元分析.
主要成果:
- 二十九项研究报告了使用各种技术的干细胞标记表达 (SOX2,OCT4,NANOG,CD44,ALDH1,BMI1,CD105).
- 偏差风险各不相同,有13项研究具有高的RoB.
- 分析表明,SOX2与乳腺癌相比,对乳腺癌和瘤有显著的区分能力.
结论:
- 干细胞可能与口腔病理病理的发病和临床行为有关.
- 干细胞标记物可能成为未来牙科个性化治疗策略的目标.
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