动物中的非核糖体合成酶
Wouter Suring1,2, Dylan Hoogduin1, Giang Le Ngoc1,3
1A-LIFE Ecology and Evolution, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.
Genes
|September 28, 2023
概括
非核糖体合成酶 (NRPSs) 是比以前认为的在动物中更常见的酶. 这项研究揭示了它们在各种动物族群中广泛存在,包括虫和线虫.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 非核糖体合成酶 (NRPSs) 是合成生物活性化合物如抗生素和 siderophores 的关键酶.
- 虽然NRPS在 prokaryotes 和 eukaryotes 中很常见,但在动物中被认为是罕见的.
- 最近在线虫,虫和关节动物中的发现促使对动物NRPS流行率进行了更广泛的调查.
研究的目的:
- 确定NRPS基因在整个动物王国的流行和分布.
- 了解动物NRPSs的进化关系.
- 确定特定的NRPS及其在动物生物化学中的潜在作用.
主要方法:
- 选了1059个动物基因组序列.
- 对已识别的NRPS基因进行了遗传学分析.
- 分析了域架构,并预测了NRPSs的基板.
主要成果:
- 在19个分析的动物类中的7个中发现了NRPS基因,这表明其分布比以前知道的更广泛.
- 遗传学分析证实NRPSs形成了与类似的酶 (如脂肪酸合成酶) 独立的独特分类.
- NRPS在虫和线虫中特别丰富,在虫中观察到不同的域架构.
- 在线虫*Plectus sambesii*和一些Collembola物种中发现了特定的β-乳酸生物合成基因.
结论:
- 动物NRPS基因比以前认可的更丰富,更广泛.
- 跨动物类的NRPS分散分布突出了它们多样化的进化历史.
- 在某些无脊椎动物中存在β-乳糖生物合成基因,这表明抗生素生产的新角色和潜力.
关键词:
甲基动物 (Metazoa) 是一种生物.在此之前,NRPS是NRPS.动物动物动物动物动物动物这是一种β-lactam.分销 销售 分销 销售 分销 销售进化 演化 演化 演化 演化 演化 演化 演化不属于核糖体的非核糖体这是一种类.人类的基因组学.合成酶是一种合成酶.更多相关视频
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