与年龄相关的认知衰退,关注微生物组:系统性审查和元分析
Donatella Coradduzza1, Stefania Sedda1, Sara Cruciani1
1Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
International journal of molecular sciences
|September 28, 2023
概括
肠道微生物组的组成在认知能力下降的个体中不同,包括阿尔茨海默氏症和帕金森病. 这一发现突显了肠道微生物组在衰老和神经退行性疾病中的潜在作用.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 衰老与生理衰退和增加疾病易感性有关.
- 认知能力下降是衰老的一个重要方面,影响神经退行性疾病.
- 人们越来越认识到肠道微生物对健康,疾病和认知功能的影响.
研究的目的:
- 系统地审查和元分析肠道微生物组与老年人群认知功能之间的关系.
- 研究与认知障碍和神经退行性疾病相关的肠道微生物组成的变化.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 在PubMed,Scopus和Web of Science中对2013-2023年期间发表的研究进行的搜索.
- 包括1303名参与者的16项研究,分析了微生物多样性和认知条件中的丰富性.
主要成果:
- 与健康对照人群相比,在患有认知障碍 (阿尔茨海默病,帕金森病,痴呆症) 的个体中观察到肠道微生物群相对丰富的显著差异.
- 关键的受影响类型包括菌,细菌菌,动菌和蛋白质菌.
- 分析揭示了阿尔茨海默病研究中的大量异质性,微生物分析的总体证据质量中等.
结论:
- 改变肠道微生物的丰富性与认知能力下降和老化中的神经退行性疾病有关.
- 肠道微生物组在认知健康和疾病进展中的作用需要进一步研究.
- 了解潜在的机制对于潜在的治疗干预在衰老和认知健康方面至关重要.
关键词:
老化的老化 衰老的老化生物标志物 生物标志物认知能力下降 认知能力下降我们的肠道微生物组.这是一个元分析.微生物多样性的微生物多样性神经退行性疾病的神经退行性疾病相对丰富的相对丰富的系统性审查 系统性审查更多相关视频
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