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口服Δ9-四大麻 (THC) 和大麻 (CBD) 对小鼠肥胖参数的影响

Adi Eitan¹, Ofer Gover¹, Liron Sulimani²

¹The Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 9190401, Israel.

International journal of molecular sciences

|September 28, 2023

概括

在老鼠中,长时间的口服 Δ9-四氨基甘醇 (THC) 摄入减少了体重增加和改善了代谢健康. Cannabidiol (CBD) 改善了葡萄糖耐受性,但没有影响体重或肥胖症,这表明THC对肥胖更有效.

科学领域:

药理学药理学是指药理学的学科.
代谢性疾病研究研究.
大麻素科学大麻素科学

背景情况:

肥胖与内分泌系统 (ECS) 有关.
大麻化合物,如 Δ9-四大麻 (THC) 和大麻 (CBD) 显示了抗肥胖的潜力.
对于肥胖的THC和CBD的口服治疗还没有得到充分的研究.

研究的目的:

研究长时间口服THC和CBD对肥胖和相关代谢参数的影响.
为了检查对外围内分泌素的影响.

主要方法:

C57BL/6雄性小鼠被养高脂肪或标准饮食.
小鼠接受了增加的THC或CBD口服剂量 (10毫克/公斤,然后30毫克/公斤) 持续10周.
评估了与肥胖相关的参数和内分泌素水平.

主要成果:

THC治疗减轻了体重增加,改善了葡萄糖耐受性,减少了肝硬化,减少了脂肪组织缩.
CBD治疗改善了葡萄糖耐受性和脂质代谢标志物,但没有影响体重增加或脂肪酸.
CBD独特地降低了肝脏的2 - 阿拉基多诺伊尔糖水平.

结论:

长时间的口服THC管理改善了小鼠的饮食引起的肥胖和相关的代谢功能障碍.
THC的影响可能涉及脂肪组织的适应.
口服CBD显示了一些代谢益处,但在这个模型中,它对体重和肥胖症的效果不如THC.

关键词:

在这里,我们可以看到CBD CBD CBD CBD.在HFD中,HFD是指HFD.在这里,我们可以看到THCTHCTH.这是内分泌大麻素 (endocannabinoids) 的作用.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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