相关实验视频

Updated: Jul 15, 2025

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Published on: May 16, 2025

新的铜复合物具有抗菌和细胞毒性活动

Adriana Corina Hangan¹, Roxana Liana Lucaciu², Alexandru Turza³

¹Department of Inorganic Chemistry, Faculty of Pharmacy, "Iuliu-Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

International journal of molecular sciences

|September 28, 2023

概括

合成了两种新的铜复合物,并根据它们的生物活性进行了表征. 复合C2表现出显著的抗菌和抗癌特性,显示出比C1.1更大的疗效.

科学领域:

无机化学无机化学
药用化学医学化学
材料科学材料科学材料科学

背景情况:

开发具有生物活性的无毒金属复合物是一个关键的研究领域.
由于其多样化的协调化学和生物作用,铜复合物正在积极研究其治疗潜力.

研究的目的:

合成和表征两种新的铜 (II) 复合物与基于亚醇的新型配体.
评估合成的铜复合物的体外抗菌和细胞毒性活动.

主要方法:

合成两种铜 (II) 复合物, [Cu4 (L1) 4 (OH) 4 (DMF) 2 (H2O)) ] (C1) 和 [Cu (L2) 2 () 2 (H2O)) ] (C2).
使用X射线晶体学,FT-IR和UV-Vis光谱学进行结构性表征.
通过微稀释方法评估抗菌活性,并使用HeLa,DLD-1和HFL1细胞系的MTT测定来评估细胞毒性.
用流式细胞计量分析了亡诱导.

主要成果:

晶体结构显示了五个协调的铜 (II) 中心,具有扭曲的正方形金字塔几何形状.
这两种复合物都在体外表现出对阳性和阴性细菌的抗菌活性.
复合C2对瘤细胞系和诱导的亡产生了增强的细胞毒性作用,这表明与C1.1相比,其生物活性更大.

结论:

合成的铜复合物C1和C2具有显著的体外生物活动.
复合C2在抗菌和细胞毒性作用方面更强大,突出其作为治疗剂的潜力.

关键词:

在Cu+2复合体中.它是一种抗菌药物,具有抗菌作用.晶体结构晶体结构细胞毒性细胞毒性

更多相关视频

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

相关概念视频

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

Extraction: Advanced Methods

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...

Metal-Ligand Bonds

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...

EDTA: Chemistry and Properties

EDTA: Chemistry and Properties

Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...

Formation of Complex Ions

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...