早期诊断缺血性中风的多层次生物标志物:系统性审查和元分析
Qianyun Li1, Lingyun Zhao1, Ching Long Chan1
1Department of Emergency Medicine, University of Hong Kong, Hong Kong, China.
International journal of molecular sciences
|September 28, 2023
概括
这项研究确定了早期缺血性中风 (IS) 诊断的有希望的血液生物标志物. 质纤维酸蛋白显示出区分中风类型的潜力,指导未来研究改进诊断工具.
科学领域:
- 神经学 神经学
- 生物标志物发现发现
- 诊断医学 诊断医学 诊断医学
背景情况:
- 早期诊断缺血性中风 (IS) 对有效治疗至关重要.
- 血液生物标志物为快速检测IS提供了一种非侵入性的方法.
- 目前关于IS诊断生物标志物的证据需要全面评估.
研究的目的:
- 系统地审查和评估早期IS诊断中血液生物标志物的证据.
- 为未来的IS研究确定最佳生物标志物和生物途径.
- 评估生物标志物的诊断性能,以区分IS与其他疾病.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Cochrane,Web of Science) 进行了系统的文献搜索.
- 使用R包meta4diag.进行了诊断元分析.
- 利用基因本体学 (GO) 分析来识别与IS相关的关键生物过程 (BP).
主要成果:
- 包括182项与30446名参与者的研究,分析了518个聚合生物标志物 (蛋白质,基因,代谢物,转录物).
- 状纤维酸蛋白显示出诊断潜力,对于HS与IS的分化 (3-24h) 的灵敏度/特异性在73-80%和77-97%之间.
- 确定了两个生物标志物 (最佳性能,低偏差) 的短清单和五个与IS相关的顶级生物途径.
结论:
- 本研究提供了IS早期诊断生物标志物的全面概述.
- 质纤维酸蛋白和已识别的生物途径需要进一步研究以获得临床应用.
- 这些发现支持开发更好的基于血液的IS诊断策略.
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