宫和阴道微生物组在早期流产和正在进行的怀孕中,有或没有使用二
Mariya Gryaznova1, Olesya Kozarenko1,2, Yuliya Smirnova1
1Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia.
International journal of molecular sciences
|September 28, 2023
概括
宫和阴道的微生物组在怀孕早期起着至关重要的作用. 特定的细菌,如Gardnerella vaginalis和Mycoplasma girerdii与流产有关,而乳杆菌和Bifidobacterium longum则提供保护.
科学领域:
- 生殖免疫学 生殖免疫学
- 微生物组研究的研究.
- 产科 产科 产科 产科 产科
背景情况:
- 生殖道微生物群影响怀孕的结果.
- 了解怀孕早期的微生物组动态对于管理生殖健康至关重要.
研究的目的:
- 在怀孕早期分析宫和阴道微生物组.
- 为了比较健康怀孕,双激素治疗和流产群体的微生物组成.
- 确定早期怀孕和流产中的关键微生物参与者.
主要方法:
- 从51名妇女 (8-11周怀孕) 收集了子宫和阴道样本.
- 在Ion Torrent PGM平台上利用16S rRNA测序进行微生物组分析.
- 在健康群体,二多固醇治疗群体和流产群体之间比较了微生物群体概况.
主要成果:
- 乳杆菌内体是占主导地位的物种,这表明CST III的流行率.
- 菌和Mycoplasma girerdii与早期流产的发病因子有显著的联系.
- 乳杆菌和Bifidobacterium longum在怀孕早期表现出一种保护作用.
- 双激素治疗显示了宫和阴道微生物组的显著差异.
结论:
- 这项研究提供了关于怀孕早期东欧人口宫和阴道微生物组的见解.
- 特定的微生物成分与妊娠结果有关,包括流产.
- 二可能会影响生殖道微生物组合.
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