肠道微生物群和衍生短链脂肪酸与心力衰竭患者的演变有关
Javier Modrego1,2, Adriana Ortega-Hernández1, Josebe Goirigolzarri3
1Laboratorio de Riesgo Cardiovascular y Microbiota, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040 Madrid, Spain.
International journal of molecular sciences
|September 28, 2023
概括
12个月后,心力衰竭患者表现出改善的肠道微生物群和短链脂肪酸 (SCFA),特别是酸盐,以及减少炎症和更好的临床结果. 这表明肠道健康和心力衰竭恢复之间存在联系.
科学领域:
- 微生物学 微生物学
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群失调和短链脂肪酸 (SCFA) 变化与心力衰竭 (HF) 病原发生有关,但直接证据有限.
- 了解肠道健康和HF进展之间的相互作用对于开发新型治疗策略至关重要.
研究的目的:
- 调查肠道微生物组成,SCFA生产,临床参数和新诊断心力衰竭患者的炎症之间的关联.
- 评估12个月内肠道微生物群和SCFA的变化,与临床改善和炎症标志物相关.
主要方法:
- 一项纵向前性研究,涉及18名新诊断的HF患者.
- 在入院和12个月后收集便和血液样本进行微生物群分析,SCFA量化和炎症标志物的评估 (细胞因子,单细胞群,内皮功能障碍).
主要成果:
- 患者在12个月后显示出改善的临床参数,减少炎症和更少的内皮功能障碍.
- 这种临床改善与肠道微生物群失调的逆转相关,有益细菌 (例如,Bifidobacterium) 的增加,以及SCFA水平的升高,特别是丁酸盐.
- 在随访期间观察到病原细菌的减少和便样本的炎症潜力降低.
结论:
- 在HF患者的发作后有利的临床过程与肠道微生物群的恢复和增加SCFA生产有关,特别是丁酸盐.
- 这些发现突显了肠道微生物组在HF中的作用,并建议针对SCFA生产或HF管理有益细菌的潜在治疗途径.
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