与自杀行为相关的严重抑郁障碍的潜在炎症生物标志物:系统性审查
Ka Young Kim1,2, Ki Young Shin3, Keun-A Chang2,4
1Department of Nursing, College of Nursing, Gachon University, Incheon 21936, Republic of Korea.
International journal of molecular sciences
|September 28, 2023
概括
大型抑郁症 (MDD) 与增加自杀风险有关. 这项研究确定了43种炎症生物标志物,包括介素-6和C反应蛋白,与MDD患者的自杀行为有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 大型抑郁症 (MDD) 影响全球2.8亿人,在精神疾病中,自杀风险最高.
- 抑郁症和自杀念头与炎症过程有关.
- 确定MDD中自杀风险的可靠生物标志物对于临床干预至关重要.
研究的目的:
- 确定与MDD患者的自杀相关行为相关的外围炎症生物标志物.
- 综合现有文献中关于炎症在MDD和自杀倾向中的作用的证据.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆的系统文献搜索2023年6月之前发表的研究.
- 包括在MDD患者中报告血液炎症生物标志物的研究,这些患者具有与自杀有关的行为.
- 在最初确定的571项研究中,分析了24项被选中的研究.
主要成果:
- 确定了与MDD和与自杀有关的行为相关的43个重要的生物标志物.
- 在MDD患者中,与自杀相关的行为中观察到外围炎症因子的显著变化.
- 关键的生物标志物包括互白素 (IL) - 1β,IL-6,C反应蛋白,C-C动机化学因子连接体2和瘤亡因子-α.
结论:
- 在MDD患者表现出与自杀相关的行为时,外围炎症因素发生显著变化.
- 像IL-1β,IL-6,CRP,CCL2和TNF-α这样的特定生物标志物显示出在MDD中显示自杀风险的潜力.
- 这些发现凸显了严重抑郁症中炎症和自杀风险之间的复杂相互作用.
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