精选的miRNA和牛皮-心血管疾病 (CVD) -超重/肥胖网络-试点研究
Anna Michalak-Stoma1, Katarzyna Walczak1, Michał Adamczyk1
1Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
International journal of molecular sciences
|September 28, 2023
概括
牛皮患者表现出与心血管疾病 (CVD) 风险相关的特定微RNA (miRNA) 的水平较低. 在超重/肥胖和正常体重的牛皮患者之间,观察到miR-22和miR-146a水平的差异.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 牛皮是一种全身性疾病,与心血管疾病 (CVD) 风险增加和肥胖有关.
- 牛皮及其并发症的确切发病因子仍然不完全理解.
- 微RNAs (miRNAs) 在各种生物过程和疾病发展中发挥作用.
研究的目的:
- 研究与心脏病风险相关的特定循环miRNAs (miR-22-3p,miR-133a-3p,miR-146a-5p,miR-369-3p,Let-7b-5p) 的差异.
- 为了比较平常体重的牛皮患者和超重/肥胖患者之间的miRNA水平.
- 探索miRNA水平,牛皮和牛皮性关节炎 (PsA) 之间的相关性.
主要方法:
- 研究包括28名男性牛皮患者和16名男性健康对照.
- 从外围血液单核细胞中分离出miRNAs.
- 使用逆转录,然后进行定量实时PCR (RT-qPCR) 来进行miRNA分析.
主要成果:
- 与对照组相比,在牛皮患者中观察到miR-22,miR-133a,miR-146a和miR-369的水平降低.
- 在超重/肥胖和正常体重的牛皮患者之间发现了miR-22和miR-146a水平的显著差异.
- 在正常体重患者的miR-22/miR-146a和PsA之间,在超重/肥胖患者的miR-133a和PsA之间发现了积极的相关性.
结论:
- 牛皮患者的miRNA水平降低与心血管疾病中观察到的水平一致,这表明在心血管疾病风险增加中发挥了作用.
- miR-22和miR-146a可能有助于链接肥胖,心血管疾病和牛皮的复杂网络.
- 这些miRNAs可以作为潜在的生物标志物,对心血管疾病的风险在牛皮患者.
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