初级Sjögren综合征中的内皮功能障碍:与疾病活动血清生物标志物的相关性
Alexandru Caraba1, Stela Iurciuc2, Mihaela Nicolin3
13rd Internal Medicine, Diabetes and Rheumatology Department, University of Medicine and Pharmacy "Victor Babeș", 300041 Timișoara, Romania.
International journal of molecular sciences
|September 28, 2023
概括
内皮功能障碍在初级Sjögren综合征 (pSS) 患者中很常见. 它与疾病活性,自身抗体和炎症标志物相关,表明系统性参与.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 主要Sjögren综合征 (pSS) 是一种慢性自身免疫性疾病,其特征是淋巴细胞透到外分泌腺体.
- 内皮功能障碍越来越多地被认为是自身免疫性疾病中的系统性表现.
- 内皮功能障碍与pSS中的特定生物标志物之间的关系需要进一步阐明.
研究的目的:
- 为了研究内皮功能障碍和主要临床和血清学标志物之间的关联在患有初级Sjögren综合征的患者.
- 评估与血清细胞因子,自身抗体 (抗SSA,抗SSB),β-2微球蛋白,焦点得分和ESSDAI的相关性.
主要方法:
- 一项涉及90名pSS患者和45名健康对照者的病例控制研究.
- 使用手臂动脉流媒扩张 (FMD) 评估内皮功能.
- 测量血清细胞因子 (TNF-α,IL-6),β-2微型血球蛋白,自身抗体和组织病理焦点评分.
主要成果:
- 与对照组相比,pSS患者的内皮功能障碍显著流行 (p < 0.00001).
- 在pSS患者中观察到TNF-α,IL-6和β-2微球蛋白的血清水平升高.
- FMD%与焦点得分,ESSDAI,抗SSA,抗SSB抗体,β-2微球蛋白,IL-6和TNF-α有显著的相关性.
结论:
- 内皮功能障碍是Sjögren综合征的重要发现.
- 内皮功能障碍的存在和严重程度与更高的疾病活性,增加的自身抗体水平,以及增加的促炎细胞因子和β-2微球蛋白有关.
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