餐后高脂血症:其病理生理学,诊断,动脉生成和治疗方法
Hidekatsu Yanai1, Hiroki Adachi1, Mariko Hakoshima1
1Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine, Kohnodai Hospital, 1-7-1 Kohnodai, Ichikawa 272-8516, Chiba, Japan.
International journal of molecular sciences
|September 28, 2023
概括
与心血管疾病相关的食后超脂血症,可以使用像apo B48和非禁食甘油三酸等标记物进行鉴定. 有效的管理包括生活方式的改变和特定的药物.
科学领域:
- 心血管医学 心血管医学
- 代谢障碍 代谢障碍 代谢障碍
- 脂质代谢 脂质代谢是什么
背景情况:
- 餐后高脂血症,以饭后血清甘油三 (TG) 水平升高为特征,是动脉样硬化心血管疾病 (ASCVD) 的重要危险因素.
- 诊断传统的口服脂肪负荷测试 (OFLT) 是耗时且不切实际的.
- 提升的TG水平与富含甘油三脂的脂蛋白 (TRLs) 的水平增加有关,包括基洛米克龙 (CM),非常低密度脂蛋白 (VLDL) 和它们的残留物 (CMR和VLDLR).
研究的目的:
- 突出了解和诊断食后高脂血症对于ASCVD预防的重要性.
- 讨论除了OFLT之外的替代诊断标记.
- 审查当前治疗策略,以管理食后高脂血症.
主要方法:
- 血清标记物的分析包括阿波利波蛋白B48 (apo B48),非禁食TG,非高密度脂蛋白胆固醇 (非HDL-C) 和残留胆固醇.
- 对表现为食后高脂血症的患者群体的审查 (例如,家族性高脂蛋白血症,代谢综合征,2型糖尿病).
- 检查食后高脂血症,高血糖和胰岛素抵抗之间的关系.
主要成果:
- 在CMR和/或VLDLR的升高表明食后高脂血症.
- 特定的标记物,如apo B48,非禁食TG,非HDL-C和残留胆固醇,可以有效地揭示食后高脂血症.
- 餐后高脂血症与代谢综合征和2型糖尿病等疾病有关,通常由胰岛素抵抗加剧.
结论:
- 准确的诊断和理解食后高脂血症对于有效的ASCVD风险管理至关重要.
- 当前的诊断标准可能不足,需要进一步研究标准化参考值.
- 改变生活方式和药理干预措施,包括抗高脂和抗糖尿病药物,有望改善结果.
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