血液ACE2蛋白水平与COVID-19的严重程度相关
Oksana Shevchuk1, Anastasia Pak1, Svitlana Palii1
1Department of Pharmacology and Clinical Pharmacology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.
International journal of molecular sciences
|September 28, 2023
概括
较高的血清血管激素转化酶2 (ACE2) 水平与较轻的COVID-19病例相关. 在康复后的轻度病例中,ACE2水平下降,但在严重病例中增加,这表明ACE2在疾病严重程度方面发挥了作用.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- ангиотензин转化酶2 (ACE2) 在COVID-19严重性中的作用仍在争论中.
- ACE2是SARS-CoV-2进入宿主细胞的关键受体.
- 伴随性疾病是已知的COVID-19严重结局的危险因素.
研究的目的:
- 调查血清ACE2水平与COVID-19严重程度之间的关联.
- 探索ACE2水平,疾病进展和常见的并发症之间的关系.
- 随着时间的推移,分析COVID-19后患者的ACE2血清水平.
主要方法:
- 从COVID-19后患者 (2020年7月至2021年12月) 的血清样本使用ELISA套件对人类ACE2蛋白进行了分析.
- 收集和统计分析了医疗记录,治疗和结果.
- 评估了ACE2水平,疾病严重程度和并发症 (高血压,心血管疾病,糖尿病,呼吸系统疾病) 之间的相关性.
主要成果:
- 患有轻度COVID-19的患者血清ACE2水平明显高于患有严重疾病的患者 (p < 0.001).
- 在轻度病例中,ACE2水平在90天内下降,但在严重病例中增加.
- 高血压,心血管疾病和糖尿病与增加的疾病严重程度和改变的ACE2血清水平相关.
结论:
- 血清ACE2水平升高可能表明COVID-19的病程不那么严重,可能是由于ACE2分泌量增加.
- ACE2脱落可能会减少病毒进入细胞,减轻疾病的严重程度.
- 某些伴随性疾病,不包括呼吸道疾病,与COVID-19的严重程度和ACE2血清水平有关.
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