受体干扰隔离生物活性在火殖民地上的杀虫效应
Satya Chinta1,2, Robert Vander Meer1, Erin O'Reilly1
1Center for Medical, Agricultural, and Veterinary Entomology, USDA-ARS, Gainesville, FL 32608, USA.
International journal of molecular sciences
|September 28, 2023
概括
新的受体i技术发现了强大的生物活性,可以有效控制红色进口火殖民地. 这些可以显著降低工人和女王的生存率,证明了一种新的害虫控制策略.
科学领域:
- 昆虫学 昆虫学是一门学科.
- 生物化学 生物化学
- 虫害管理 虫害管理 虫害管理
背景情况:
- G蛋白结合受体 (GPCRs) 是重要的药物标.
- 受体干扰 (Receptor-i) 是一种用于识别受体特异生物活性的新技术.
- 红色进口火 (Solenopsis invicta) 构成了严重的农业和医学威胁.
研究的目的:
- 利用受体i技术识别针对火激素生物合成激活神经受体 (PBAN-R) 的新型防虫剂.
- 评估已识别的生物活性对Solenopsis invicta.野外殖民地的疗效.
主要方法:
- 根据先前的研究,选择了四种循环生物活性.
- 进行了小规模的养生物测试,以评估工人死亡率.
- 在已建立的火殖民地进行了大规模的养试验,使用最有效的.
主要成果:
- 两个,CMARYMSAC (MARY) 和CIQQGSHFC (IQQG),显示出显著的疗效.
- 到第84天,MARY和IQQG治疗导致工人死亡率分别超过80%和70%.
- 接受治疗的女王经历了显著的体重减轻,与对照殖民地不同,殖民地繁殖受到了影响.
结论:
- 接收器-i技术成功地确定了用于防火的强有力的生物活性.
- 鉴定的,特别是MARY和IQQG,显示出作为新型害虫防治剂的巨大潜力.
- 这项研究提供了Receptor-i的概念验证及其对其他农业和医疗害虫的适用性.
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