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肌肉IGF1-IGFBP5-PAPP系统的时间依赖的变化,在阴道肌缩后.

Ana Isabel Martín1, Álvaro Moreno-Rupérez1, Elena Nebot1

  • 1Departamento de Fisiología, Facultad de Medicina, Universidad Complutense de Madrid, Plaza de Ramón y Cajal sn, 28040 Madrid, Spain.

International journal of molecular sciences
|September 28, 2023
PubMed
概括

坐骨 sciatic 缩通过改变 IGF-1 系统导致肌肉缩. 早期的帕帕林素 (PAPP-A) 增加可能有助于肌肉生长,但随后的下降,以及高的IGFBP-5水平,会导致疲劳.

关键词:
在IGF-1的基础上,IGF-1在 IGFBP-5 中.帕帕利西尼斯是一种胰岛素.骨肌肉缩 骨肌肉缩

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科学领域:

  • 肌肉生理学和分子生物学
  • 骨肌疾病的机制 骨肌疾病的机制
  • 内分泌学和生长因子信号传导.

背景情况:

  • 肌缩引起的肌肉缩是一个重要的临床问题.
  • 胰岛素样生长因子1 (IGF-1) 对于肌肉生长至关重要,但其在缩中的作用尚不清楚.
  • IGF-1活动是由IGF-1结合蛋白 (IGFBPs) 和帕帕利辛 (PAPP-A) 调节的.

研究的目的:

  • 为了研究依赖于时间的IGF1-IGFBP5-PAPP系统的变化,在腹肌肌经过坐骨 sciatic剥皮后.
  • 了解影响肌肉缩期间IGF-1生物可用性的调节机制.

主要方法:

  • 动物的坐骨 sciatic 变性模型.
  • 消化肌肌肉组织在不同时间点的分析.
  • 测量IGF-1,IGFBP-5和PAPP-A的表达和活性.
  • 对蛋白质溶解标记物的评估.

主要成果:

  • 肌肉缩和IGF-1过度表达从退神后的第三天就显而易见.
  • 蛋白质分解因子和IGFBP-5和PAPP-A的表达在早期 (1-3天) 增加.
  • 在第7-14天,PAPP-A水平恢复到基线,而IGFBP-5仍然很高,IGFBP-5/PAPP-A比率与蛋白质分解标志物相关.

结论:

  • 在PAPP-A的早期上升可能最初支持IGF-1的合成作用.
  • 随后PAPP-A的下降加上持续的IGFBP-5升高可能会加剧肌肉衰竭.
  • IGF1-IGFBP5-PAPP轴是肌肉质量的关键调节器,在肌肉变质后发生变质.