多囊性卵巢综合征和氧化应激-从长椅到床边
Natalia Zeber-Lubecka1,2, Michał Ciebiera3,4, Ewa E Hennig1,2
1Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
International journal of molecular sciences
|September 28, 2023
概括
氧化应激 (OS) 通过损害卵巢功能和引起胰岛素抵抗,导致多囊性卵巢综合征 (PCOS). 了解这种联系是开发PCOS新治疗方法的关键.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 细胞生物学 细胞生物学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 氧化应激 (OS) 源于反应性氧物种 (ROS) 和抗氧化防御之间的不平衡.
- OS与各种生殖条件有关,包括多囊性卵巢综合征 (PCOS).
- 线粒体功能障碍,其特点是氧化酸化 (OXPHOS) 受损和ATP生产减少,增加ROS并导致PCOS病理生理学.
研究的目的:
- 审查氧化应激和多囊性卵巢综合征 (PCOS) 之间的复杂关系.
- 阐明OS影响卵巢功能和PCOS代谢失调的机制.
- 讨论抗氧化剂在治疗PCOS中的潜在治疗作用.
主要方法:
- 文献综述侧重于OS和PCOS之间的分子和细胞联系.
- 对研究线粒体功能,ROS产量和PCOS中胰岛素耐药性的研究进行分析.
- 对OS对卵巢毛囊,卵细胞和粒状细胞的影响的研究进行了审查.
主要成果:
- OS对卵巢卵泡产生负面影响,扰乱发育和成熟,并损害卵细胞和粒状细胞,从而损害生育能力.
- 损坏的OXPHOS和线粒体功能障碍通过破坏胰岛素信号传递和葡萄糖代谢,导致胰岛素抵抗 (IR).
- 过高雄性症通过炎症和IR加剧OS,创造一个有害的反循环,使PCOS症状恶化.
结论:
- 氧化应激是PCOS病理生理学的重要因素,影响生殖和代谢方面.
- 准OS和改善线粒体功能可能为PCOS提供新的治疗策略.
- 对抗氧化剂的进一步研究是有必要的,以探索它们作为PCOS治疗的潜力.
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