恢复 ангиотензин 2 型受体功能 逆转PFOS诱导的血管过敏反应和高血压在怀孕期间
Sri Vidya Dangudubiyyam1,2, Bradley Bosse3, Pankaj Yadav1
1Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA.
International journal of molecular sciences
|September 28, 2023
概括
在怀孕期间暴露于 perfluorooctane sulfonic acid (PFOS) 会导致高血压. 用化合物21 (C21) 激活血管素2型受体 (AT2R) 逆转了这些影响,改善了母亲的血管功能和胎儿的生长.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 心血管生理学心血管生理学
背景情况:
- 在怀孕期间暴露于 perfluorooctane sulfonic acid (PFOS) 与妊娠期高血压和血管功能受损有关.
- 暴露于PFOS会降低血管扩张性血管新生素2型受体 (AT2R) 表达,从而导致孕产妇和胎儿的并发症.
研究的目的:
- 调查AT2R激活是否可以恢复血管激素1型受体 (AT1R) 和AT2R之间的平衡.
- 为了确定AT2R激活是否可以逆转PFOS诱导的妊娠高血压,并改善血管机制.
主要方法:
- 怀孕的斯普拉格-道利大鼠从怀孕4-20天通过饮用水暴露在PFOS中.
- 暴露于PFOS和对照大鼠从怀孕15-20日开始接受AT2R激动剂化合物21 (C21).
- 评估了母亲的血压,子宫动脉血流,血管反应能力和胎盘生长.
主要成果:
- 暴露于PFOS会增加母亲的血压,并减少子宫动脉的血流.
- 在暴露于PFOS的女性中,C21治疗逆转了这些影响,使血压正常化并改善了血液流动.
- C21缓解了强烈的Ang II收缩,增强了血管松,并增加了AT2R和eNOS蛋白水平.
- C21治疗减轻了胎盘生长限制和增加了血布拉迪基宁.
结论:
- 用C21激活AT2R可以改善PFOS诱导的母体血管功能障碍和胎盘血流.
- 向AT2R可能提供一种治疗策略,以防止与PFOS暴露相关的不良孕产妇和胎儿后果.
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