在聚烯酸和含相上构建的电复合材料的开发和表征
Cristiana Plocon1, Alexandru Evanghelidis2, Monica Enculescu2
1University Politehnica of Bucharest, RO-060042 Bucharest, Romania.
International journal of molecular sciences
|September 28, 2023
概括
这项研究开发了聚烯酸 (PCL) 复合性支架,其中包含含 (Ce) 的粉末,用于增强骨再生. 酸含有Ce的酸盐表现出优异的生物相容性和抗菌性质,显示出对骨科应用的希望.
科学领域:
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
- 纳米技术纳米技术
背景情况:
- 聚烯酸 (PCL) 是一种可生物降解的聚合物,广泛用于组织工程.
- 含 (Ce) 的化合物有可能提高生物活性和生物材料中的抗菌特性.
- 开发具有定制性质的复合脚手架对于有效的骨再生至关重要.
研究的目的:
- 制造和表征PCL基复合材料支架,其中包含各种含 (Ce) 粉末.
- 评估已开发的脚手架的组成,结构,形态,光学和生物特性.
- 为了评估复合脚手架的生物活性,抗菌作用和生物相容性,以潜在的骨科应用.
主要方法:
- 使用湿化学方法 (沉/共沉,sol-gel) 合成CeO2,Ce化酸盐和Ce替代生物玻璃.
- 通过电将合成的粉末加载到PCL纤维上,以创建复合材料支架.
- 粉末和支架的表征使用技术来评估相位组成,形态和结构.
- 在体外评估生物活性 (沉浸在模拟体液中 - - SBF),抗菌活性和与人类骨质细胞的生物相容性.
主要成果:
- 含有Ce的粉末已成功合成并纳入PCL纤维,形成纳米或微米结构.
- 酸含有Ce的酸盐表现出显著的抗菌作用,特别是在较低温度下化时.
- 含有Ce的生物玻璃显示出最高的生物活性.
- 复合性支架与人类骨质细胞具有出色的生物相容性,PCL与Ce-doped酸盐相结合,观察到更好的反应.
- 通过调整聚合物度,可以控制脚手架形态,从而产生更有序的纤维.
结论:
- 基于PCL和含有的粉末的复合支架显示了骨组织工程应用的巨大潜力.
- Ce-doped酸为骨科植入物提供了抗菌性质和生物相容性的有希望的组合.
- 开发的制造方法允许为提高生物性能量身定制脚手架的特性.
关键词:
这就是CeO2 .生物玻璃是一种生物玻璃.酸和酸的作用电力旋转是指电力旋转.聚卡普罗拉克托尼是一种多重的产物.脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架.更多相关视频
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