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Updated: Jul 15, 2025

Cryo-EM and Single-Particle Analysis with Scipion
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Cryo-EM and Single-Particle Analysis with Scipion

Published on: May 29, 2021

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Scipion-EM-ProDy:Scipion工作流引擎中的ProDy Python包的一个图形接口,可以集成数据库,模拟和冷电子显微镜图像处理.

James M Krieger1, Carlos Oscar S Sorzano1, Jose Maria Carazo1

  • 1Biocomputing Unit, National Centre for Biotechnology (CNB CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, Cantoblanco, 28049 Madrid, Spain.

International journal of molecular sciences
|September 28, 2023
PubMed
概括

这项研究将ProDy Python API集成到Scipion工作流引擎中,为更广泛的用户群增强对宏分子动力学分析的访问权限. 该Scipion-EM-ProDy插件为研究蛋白质动态提供先进的计算工具.

关键词:
冷电子显微镜的使用方法弹性网络模型的弹性网络模型整体分析 整体分析全球蛋白质动力学混合动力模拟,混合动力模拟.正常模式分析正常模式分析主要组件分析的主要组件分析软件集成工作流程的工作流程.

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Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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