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肺癌和慢性阻塞性肺病的金属学特征

Belén Callejón-Leblic¹, Saida Sánchez Espirilla^1,2, Carolina Gotera-Rivera³

¹Department of Chemistry, Research Center for Natural Resources, Health and the Environment (RENSMA), Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Fuerzas Armadas Ave., 21007 Huelva, Spain.

International journal of molecular sciences

|September 28, 2023

概括

金属学揭示了与肺癌 (LC) 和慢性阻塞性肺病 (COPD) 相关的血清中的明显元素变化. 这些发现可能有助于确定这些与烟草有关的疾病的生物标志物.

科学领域:

金属学和微量元素分析
环境健康和毒理学
瘤学和呼吸系统医学

背景情况:

肺癌 (LC) 是癌症死亡的主要原因.
慢性阻塞性肺病 (COPD) 是LC的重要危险因素.
了解这些与烟草有关的疾病的共同病因至关重要.

研究的目的:

调查金属学在了解LC和COPD方面的作用.
分析健康个体,LC患者和COPD患者的血清元素概况.
探索与COPD严重程度和LC相关的基本特征.

主要方法:

观察性研究涉及191个人类血清样本.
使用金属学技术分析了18种元素 (例如V,Al,As,Mn,Cu,Zn,Cd,Pb,Ni).
对不同患者群体和COPD严重程度的元素概况进行比较.

主要成果:

在COPD和LC患者中观察到血清元素组成的显著变化.
慢性肺炎的严重程度与血清A,Cd,Tl的降低以及Mn,Sb的增加相关.
肺癌与血清Al,As,Mn和Pb度的增加有关.

结论:

血清元素概况受到COPD和LC的显著影响.
某些特定元素显示出作为诊断和预测LC和COPD的生物标志物的潜力.
这项研究提供了COPD进展和肺癌发展之间的联系的见解.

关键词:

慢性阻塞性肺病慢性阻塞性肺病感应合的血是诱导合的.肺癌是一种肺癌.质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量金学金学是一门学科.金属是金属,金属是金属.

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