Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
Aging01:26

Aging

72
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
72
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Overview of DNA Repair02:25

Overview of DNA Repair

31.1K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
31.1K
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

36
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
36
Replication in Eukaryotes01:29

Replication in Eukaryotes

13.9K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
13.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Single-domain antibodies as potent inhibitors of clinically relevant <i>β</i>-lactamases in multidrug-resistant bacteria.

Frontiers in microbiology·2026
Same author

From gatekeepers to mitochondrial mischief: how bacterial outer membrane proteins crash the host cell party.

FEMS microbiology reviews·2025
Same author

Fungal Drug Response and Antimicrobial Resistance.

Journal of fungi (Basel, Switzerland)·2023
Same author

Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca<sup>2+</sup> homeostasis in yeast.

Frontiers in microbiology·2023
Same author

Divergence of alternative sugar preferences through modulation of the expression and activity of the Gal3 sensor in yeast.

Molecular ecology·2023
Same author

Editorial: Microbial Stress Responses: Antioxidants, the Plasma Membrane, and Beyond.

Frontiers in microbiology·2022
Same journal

RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

International journal of molecular sciences·2026
Same journal

Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

International journal of molecular sciences·2026
Same journal

Correction: Borovikov et al. The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders. <i>Int. J. Mol. Sci</i>. 2025, <i>26</i>, 6705.

International journal of molecular sciences·2026
Same journal

Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

International journal of molecular sciences·2026
Same journal

Correction: Guo et al. Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanism of Flavonoid Biosynthesis in Maize Roots Under Lead Stress. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6050.

International journal of molecular sciences·2026
Same journal

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026
查看所有相关文章

相关实验视频

Updated: Jul 15, 2025

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

15.7K

在衰老过程中基因组不稳定性和表观遗传变化.

Lucía López-Gil1,2, Amparo Pascual-Ahuir1, Markus Proft2

  • 1Department of Biotechnology, Instituto de Biología Molecular y Celular de Plantas, Universitat Politècnica de València, Ingeniero Fausto Elio s/n, 46022 Valencia, Spain.

International journal of molecular sciences
|September 28, 2023
PubMed
概括
此摘要是机器生成的。

基因组不稳定性,包括DNA损伤和表观遗传变化,驱动衰老. 了解这些机制是未来衰老研究和干预的关键.

关键词:
衰老的衰老 衰老的衰老在这种情况下,染色染色素表观遗传学是指表观遗传学.基因组的不稳定性基因组 基因组 基因组

更多相关视频

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

12.6K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.5K

相关实验视频

Last Updated: Jul 15, 2025

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

15.7K
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

12.6K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.5K

科学领域:

  • 老年学是指老年学的学科.
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 衰老的特点是生理衰退和死亡率的增加.
  • 基因组不稳定性越来越被认为是衰老的关键标志.
  • 随着年龄的增长,细胞和分子的变化会累积起来.

研究的目的:

  • 审查基因组不稳定性在衰老过程中的核心作用.
  • 探索导致与衰老相关的基因组不稳定性的遗传和表观遗传变化.
  • 讨论染色体组织对衰老的影响.

主要方法:

  • 关于衰老和基因组不稳定性的科学文章的文献综述.
  • 对遗传变化的分析 (端粒缩短,DNA损伤,修复能力).
  • 检查表观遗传修饰 (基因组,DNA甲基化,非编码RNA) 和染色质结构.

主要成果:

  • 端粒缩短,DNA损伤积累和DNA修复能力降低是衰老的关键遗传因素.
  • 表观遗传变化,包括基因组修饰,改变的DNA甲基化和非编码RNA,在衰老中很普遍.
  • 染色体组织的变化,如异性染色体的损失和重塑,在衰老过程中导致基因组不稳定.

结论:

  • 基因组不稳定是衰老过程的一个基本驱动因素.
  • 遗传,表观遗传和染色质的改变共同导致衰老.
  • 进一步的研究对于阐明这些复杂的生物机制及其影响至关重要.