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非酒精性脂肪肝疾病和左心室透气功能的心声学参数:系统性审查和元分析
Athina Goliopoulou1, Panagiotis Theofilis2, Evangelos Oikonomou1
13rd Department of Cardiology, Sotiria Chest Disease Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
International journal of molecular sciences
|September 28, 2023
概括
非酒精性脂肪肝疾病 (NAFLD) 与左心室扩张功能受损有关. 这一元分析证实,NAFLD患者表现出较差的透气功能,支持其与心力衰竭与保留射出分数 (HFpEF) 的关联.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 越来越多地被认可为其心血管影响,特别是与心力衰竭与保留射出分数 (HFpEF) 的关联.
- 了解NAFLD的亚临床心脏变化对于早期风险分层和干预至关重要.
研究的目的:
- 系统地审查和元分析NAFLD与左心室透气功能的心声标志物之间的关联.
- 为了研究NAFLD和特定的腹功能障碍参数之间的相关性:E/e,左心房体积指数 (LAVi) 和左心室质量指数 (LVMi).
主要方法:
- 在PubMed和Embase进行了全面的文献搜索,寻找相关的原创研究.
- 对31项使用R研究的研究进行了元分析,分析了透支功能障碍患病率,E/e',LAVi和LVMi.
- 结果表达为几率比率 (OR) 和标准化平均差异 (SMD) 与95%置信区间 (CI).
主要成果:
- 分析显示,在NAFLD患者中,扩张性功能障碍的患病率增加 (OR: 2.07).
- 在NAFLD患者中观察到显著更高的E/e' (SMD: 1.02),LAVi (SMD: 0.87),和LVMi (SMD: 0.89).
- 在几个分析中 (I2 > 80%) 发现了很高的异质性.
结论:
- 这项对31项研究的综合元分析提供了强有力的证据,表明NAFLD与左心室扩张功能受损有关.
- 观察到的心声学变化支持了NAFLD有助于心力衰竭的发展或进展的假设.
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