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侵袭性乳腺癌中的ASAP1表达及其预后作用

Hosub Park¹, Hwangkyu Son¹, Hyebin Cha¹

¹Department of Pathology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Republic of Korea.

International journal of molecular sciences

|September 28, 2023

概括

乳腺癌患者的低ASAP1表达与更差的生存结果有关. 这一发现表明,ASAP1水平可能是侵入性乳腺癌的预后标志物,影响无复发和整体存活率.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

乳腺癌是一个重大的全球健康挑战,死亡率高.
提高ASAP1表达以前与几种癌症类型的预后不佳有关.

研究的目的:

研究ASAP1表达在侵袭性乳腺癌中的预后意义.
为了将ASAP1水平与患者生存率和临床病理特征相关联.

主要方法:

在452名乳腺癌患者中使用免疫组织化学染色对ASAP1表达的分析.
ASAP1表达水平 (高与低) 与整体存活率,无复发存活率和无进展存活率的相关性.
多变量考克斯回归分析和TCGA数据集分析.

主要成果:

低ASAP1表达与整体队列中更差的无复发生存率显著相关 (p = 0.029).
在ER阳性病例中,低ASAP1表达与较差的整体存活率 (p = 0.039) 和无复发存活率 (p = 0.029) 相相关.
低ASAP1表达独立预测了总体 (HR = 2.566,p = 0.002) 和ER阳性 (HR = 4.046,p = 0.002) 组的无复发性生存率较差,以及TCGA数据中的无进展性生存率较差 (p = 0.005).

结论:

低ASAP1表达作为一种独立的预后标记,用于侵袭性乳腺癌中不利的无复发生存.
ASAP1表达水平可能为预测患者的结果提供有价值的见解,特别是在ER阳性乳腺癌中.

关键词:

有 SH3 域的 ArfGAP.PH PH域1 PH域1 PH域1 PH域1 PH域1 PH域1 PH域1 安基林重复重复侵袭性乳腺癌的癌症.预后预后预后

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