在C型肝炎消除时代,预防肝细胞癌
Jeffrey V Lazarus1,2,3, Camila A Picchio3, Massimo Colombo4
1HPAM, CUNY Graduate School of Public Health and Health Policy (CUNY SPH), New York, NY 10027, USA.
International journal of molecular sciences
|September 28, 2023
概括
肝炎C病毒 (HCV) 导致肝癌 (HCC). 虽然直接抗病毒药物 (DAA) 可以治愈HCV,但HCC风险仍然存在,需要对已治愈的患者进行监测和生物标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 肝炎C病毒 (HCV) 是导致肝细胞癌 (HCC) 的全球主要原因.
- 引起HCV的HCC死亡率很高,特别是在西方国家.
- 病毒蛋白和慢性炎症驱动HCV的致癌潜力.
研究的目的:
- 为了强调与HCV相关的HCC的持续威胁.
- 强调需要整合的策略,预防和治疗HCV,特别是注射毒品的人 (PWID).
- 解决治愈的HCV患者中持续存在的HCC风险和监测的需要.
主要方法:
- 对HCV病原和流行病学的审查.
- 用直接抗病毒药物 (DAA) 治疗结果的分析.
- 讨论治愈人口中HCC的风险因素和监测需求.
主要成果:
- 在大多数患者中,DAA可以消除HCV感染.
- 治愈HCV可显著降低,但不能消除HCC的风险.
- 伴随疾病的老年人群在HCV治愈后面临加快的HCC进展.
结论:
- 早期检测,预防和DAA治疗对于控制HCV和减少HCC至关重要.
- 对PWID的综合护理和降低危害对于消除HCV至关重要.
- 风险分层监测和预测生物标志物对于治愈的HCV患者的HCC预防是必要的.
关键词:
这是一种α-fetoprotein.直接作用的抗病毒疗法.在C型肝炎病毒的感染中,肝细胞癌是肝细胞癌.肝脏硬 肝脏硬 肝脏硬监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督持续的病毒学反应.超声波超声波是指超声波的使用.更多相关视频
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