L-卡尼丁和男性生育能力:补充有益吗?
Filipa G Mateus1, Silvia Moreira1,2,3, Ana D Martins2
1Department of Medical Science, University of Aveiro, 3810-193 Aveiro, Portugal.
Journal of clinical medicine
|September 28, 2023
概括
补充L-Carnitine通过提高精子参数和减少氧化应激,有望改善男性生育能力. 需要进一步的研究,以充分了解其机制和最佳剂量,以改善男性生殖健康.
科学领域:
- 生殖生物学 生殖生物学
- 线粒体生理学线粒体生理学
- 营养科学 营养科学
背景情况:
- L-卡尼丁对于脂肪酸运输到线粒体至关重要.
- 它具有抗氧化特性,可以减轻活性氧物种 (ROS) 的损害.
- 它在男性不孕症和塞尔托利细胞功能中的作用正在调查中.
研究的目的:
- 审查当前关于L-卡尼丁益处的知识.
- 探索其在男性 (不) 育力中的特定作用.
- 巩固体外,临床前和人体研究的发现.
主要方法:
- 审查涉及塞尔托利细胞的体外研究.
- 对L-Carnitine临床前研究的分析.
- 检查不育男性的临床研究.
主要成果:
- L-卡尼丁对塞尔托利细胞产生积极影响,有助于生殖细胞的发育.
- 每天2克的补充剂改善了精子参数和激素水平.
- 观察到ROS水平降低和抗氧化酶活性增强.
结论:
- L-卡尼丁对男性生育能力有潜在的益处.
- 它可以通过抗氧化机制改善精子质量和生育率.
- 需要进一步研究以阐明机制并确定最佳剂量.
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