孕妇严重至危急COVID-19的危险因素
María Guadalupe Berumen-Lechuga1, Alfredo Leaños-Miranda2, Carlos José Molina-Pérez3
1Medical Research Coordinator, Instituto Mexicano del Seguro Social, Órgano de Operación Administrativa Desconcentrada Regional Poniente, Josefa Ortiz de Domínguez S/N Colonia Centro, Toluca CP 50000, Mexico.
Journal of clinical medicine
|September 28, 2023
概括
未接种疫苗的孕妇,非O型血型的孕妇和年长的母亲面临更高的严重COVID-19风险. 慢性高血压和晚期妊娠年龄也会增加严重的冠状病毒疾病2019在怀孕中的严重程度.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 孕妇是受到COVID-19严重后果的脆弱人群.
- 目前关于COVID-19风险因素的研究主要集中在一般人群上,对孕妇的具体数据有限.
- 这项研究解决了了解孕妇严重危急COVID-19风险因素的差距.
研究的目的:
- 确定和量化与孕妇严重危机性COVID-19感染相关的风险因素.
- 在COVID-19大流行期间为孕妇提供数据,以告知临床管理和公共卫生策略.
主要方法:
- 进行了一项多中心病例控制研究,涉及758名感染SARS-CoV-2的孕妇.
- 根据世卫组织的标准,妇女被分为严重至关键的COVID-19病例 (n=123) 和非严重的COVID-19对照 (n=635).
- 使用多变量逻辑回归分析来确定确定风险因素的调整赔率比率.
主要成果:
- 怀孕期间严重至关重要的COVID-19的主要危险因素包括未接种疫苗 (OR 10.18),O以外的血型 (OR 6.29),35岁以上的母亲年龄 (OR 5.76),和慢性高血压 (OR 5.12).
- 其他重要因素是感染时的妊娠年龄≥31周 (OR 3.28) 和多对性 (OR 2.80).
结论:
- 非接种疫苗,非O型血型,晚期孕产妇年龄,慢性高血压,感染时晚期妊娠年龄和多夫妇是孕妇严重危急COVID-19的重要危险因素.
- 这些发现突出了需要更密切监测和潜在优先干预的孕妇特定子组.
- 结果强调了疫苗接种和在流行病期间在孕妇中主动管理伴随性疾病的重要性.
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