脱脂症治疗的现在和未来-一篇评论
Iveta Merćep1,2, Andro Vujević2, Dominik Strikić2
1Department of Internal Medicine, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Journal of clinical medicine
|September 28, 2023
概括
心血管疾病 (CVD) 是一个主要的健康负担. 新疗法针对LDL胆固醇以外的脂质不良症,以减少残留心血管风险,提供不断变化的治疗选择.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是一个重大的全球健康挑战.
- 改变生活方式和准脂质不良症,特别是高的LDL胆固醇,是预防心血管疾病的关键.
- 目前的他类药物治疗有效降低了LDL胆固醇,但由于其他脂蛋白异常,通常会留下残留的心血管风险.
研究的目的:
- 审查目前治疗失脂症的治疗策略.
- 讨论针对新型脂质通路的新批准和新兴药物.
- 突出心血管疾病风险管理的不断变化的格局.
主要方法:
- 对当前和正在发展的失脂症治疗方法的文献综述.
- 对新型降脂剂的最新研究进行分析.
- 综合了针对富含甘油三脂的脂蛋白,脂蛋白 (a) 和脂蛋白C和B的治疗选择的信息.
主要成果:
- 虽然降低LDL胆固醇是有效的,但残留风险仍然存在.
- 新兴疗法向富含甘油三的脂蛋白,脂蛋白 (a) 和脂蛋白C和B.
- 一些新药在降低总脂质水平方面表现有前途,尽管心血管事件数据尚未公布.
结论:
- 脱脂症的治疗正在发展到不仅仅是降低LDL胆固醇.
- 新的治疗点和药物正在出现,以解决残留心血管风险.
- 脱脂症管理的未来涉及到更广泛的药理选择.
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