血清炎症和氧化应激标记在患有白风的患者
Asma Kassab1,2, Yassine Khalij1, Yosra Ayed2
1Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, University of Monastir, Monastir 5019, Tunisia.
Journal of clinical medicine
|September 28, 2023
概括
Vitiligo 病原包括氧化应激和炎症,在患者中观察到较低的抗氧化剂水平和较高的炎症标志物,如 IL-15 和化学因子 (CXCL9,CXCL10). 向IL-15可能为白风提供一种新的治疗方法.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 生物化学 生化学
背景情况:
- Vitiligo 是一种慢性皮肤疾病,其特征是皮肤色素丧失.
- 它的病因是复杂的,涉及遗传和环境因素.
- 与氧化还原状态,炎症和免疫相关的关键标志物与白风病原发生有关.
研究的目的:
- 调查与白风病原发生相关的关键标志物.
- 分析白风患者的氧化还原状态,炎症和免疫特征.
- 为了比较活跃和稳定的非细分性白风之间的这些标志物.
主要方法:
- 一项涉及96名参与者的研究:30名活跃白风患者,30名稳定白风患者和36名对照患者.
- 评估白风区域严重性指数 (VASI) 和白风疾病活动评分 (VIDA).
- 测量血清参数,包括抗氧化状态 (TAS),氧化应激标志物 (MDA,AOPP),炎症细胞因子 (CRP,IL-15) 和化学因子 (CXCL9,CXCL10).
主要成果:
- 与对照组相比,白病患者的抗氧化剂标志物 (TAS,CAT,GPx,GST) 显著降低,氧化应激标志物 (MDA,AOPP) 较高.
- 在白病患者中观察到高水平的C-反应蛋白 (CRP),中白素-15 (IL-15) 和化学激素 (CXCL9,CXCL10).
- 与稳定的白风相比,活跃白风的抗氧化活性较低,CRP,CXCL9和CXCL10水平较高,而SOD在活跃白风中较高.
结论:
- 白风的氧化损伤与增加的促炎性IL-15和IFN-γ诱导化学因子 (CXCL9,CXCL10) 有关.
- 发现了VASI得分和IL-15水平之间的潜在相关性.
- 抑制IL-15为白风提供了一个有前途的治疗策略,针对氧化应激和免疫反应之间的相互作用.
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