主要免疫缺陷患者中COVID-19的长期后果:加拿大前性基于人口的研究
Justine Benoit-Piau1, Karine Tremblay2, Alain Piché3
1Research Center of the Centre Hospitalier Universitaire de Sherbrooke (CHUS), University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Journal of clinical medicine
|September 28, 2023
概括
近一半的人经历了COVID-19后的疾病 (PCC),症状持续超过三个月. 风险因素包括女性性别,症状严重程度和先前的心理健康状况,影响生活质量.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 后COVID-19状态 (PCC) 涉及在SARS-CoV-2感染后持续的症状.
- 对于PCC的持续时间,严重程度和对工作和精神健康的长期影响,在原始人群中尚不清楚.
- 这项研究解决了有关慢性后病毒综合征的知识差距.
研究的目的:
- 为了确定COVID-19后症状的结果.
- 确定与发展PCC相关的风险因素.
- 评估PCC对工作和心理健康的影响.
主要方法:
- 基于人口的前性队列研究.
- 在加拿大三个地区招募了1349名18岁以上的COVID-19成年人 (2020年11月至2021年5月).
- 通过问卷 (电话或在线) 评估多达9个月的症状.
主要成果:
- 48.0%的参与者在COVID-19后至少三个月报告了一种或多种症状.
- 在PCC患者中,23.0%-37.8%的人报告疲劳.
- 患PCC的危险因素包括女性性别,急性感染期间症状数量/严重程度较高,以及先前存在的心理健康状况.
结论:
- 近一半 (47%) 的参与者在急性SARS-CoV-2感染后经历了超过3个月的持续症状.
- 女性性别,急性感染症状负担和先前的心理健康诊断是PCC的关键风险因素.
- PCC显著影响生活质量,增加心理痛苦和疲劳.
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