瓦尔酸相关的急性胰腺炎:系统性文献综述
Monica C M Bischof1, Mariana I E Stadelmann1, Simone Janett2,3
1Family Medicine Institute, Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland.
Journal of clinical medicine
|September 28, 2023
概括
长期使用酸可以导致急性胰腺炎,这是一个严重的疾病. 这项审查发现胰腺炎在治疗期间随时可能发生,并且死亡率很高,特别是在儿童中.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 神经学 神经学
背景情况:
- 瓦尔酸是一种广泛使用的抗和情绪稳定药物.
- 长期的酸治疗与急性胰腺炎有关.
- 了解酸诱导的胰腺炎的特征对于患者管理至关重要.
研究的目的:
- 调查与酸治疗相关的急性胰腺炎的临床特征和结果.
- 为了确定酸诱导的胰腺炎的风险因素和模式.
主要方法:
- 在主要的生物医学数据库 (PubMed,Embase,Web of Science,Google Scholar) 进行了预先注册的文献搜索.
- 纳入标准侧重于与酸相关的急性胰腺炎病例,不包括其他已知的原因.
- 分析了来自73份报告 (1979-2023) 的数据,描述了125名患者 (83名儿童,42名成年人).
主要成果:
- 急性胰腺炎发生在开始服用瓦尔酸后的平均11个月后.
- 总体死亡率为16%,幸存者和非幸存者之间风险因素没有显著差异.
- 在19名患者的valproic acid重复挑战导致84%的胰腺炎复发.
结论:
- 瓦尔酸诱导的胰腺炎是一种显著的不良事件,可以在治疗期间的任何时候表现出来.
- 这种情况带来了高死亡风险,特别是在儿科患者中.
- 意识和及时识别对于管理这种严重并发症至关重要.
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