代谢综合征中的短期心率变化:系统审查和元分析
Johan E Ortiz-Guzmán1, Sara Mollà-Casanova2,3, Pilar Serra-Añó2,3
1Department of Physiology, Universitat de València, Av. Blasco Ibáñez 15, 46010 Valencia, Spain.
Journal of clinical medicine
|September 28, 2023
概括
患有代谢综合征 (MS) 的患者表现出短期心率变化 (HRV) 的改变,显示了像SDNN和rMSSD这样的缩短时间域指标. 频域分析还显示了较低的HF和LF,观察到性别特异性差异.
科学领域:
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
- 身体生理学 身体生理学
背景情况:
- 代谢综合征 (MS) 是一组增加心血管风险的疾病.
- 心率变化 (HRV) 反映了自主神经系统的功能,是MS的潜在生物标志物.
- 了解MS中的HRV差异对于风险分层和风险管理至关重要.
研究的目的:
- 与健康对照人群相比,系统地审查和元分析MS患者的短期HRV.
- 调查与MS相关的HRV的潜在性别特异性差异.
主要方法:
- 对短期HRV记录 (≤30分钟) 的研究进行系统审查和元分析 (MA).
- 搜索电子数据库进行比较研究 (MS与健康对照).
- 遵守PRISMA指导方针和PROSPERO注册 (CRD42022358975) 的要求.
主要成果:
- 19项研究符合MA标准; 28项研究符合定性综合的标准.
- 多发性硬化患者的SDNN,rMSSD,HF和LF显著下降.
- 分分析揭示了性别特异性模式:女性的SDNN,rMSSD和HF较低;男性的LF较低. 对于非线性变量的MA是不可能的.
结论:
- 代谢综合征与短期HRV的显著变化有关,特别是在时间域 (SDNN,rMSSD) 和频域 (HF,LF) 的测量方面.
- 性别分析表明,MS对男性和女性HRV的影响不同,突显了需要采用性别分层方法的需要.
- 这些发现强调了HRV作为MS自主功能障碍的有价值指标.
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