雷巴米皮德对肠道屏障,肠道微生物群结构和功能的影响,以及与易怒肠综合征和功能性消化不良症重叠相关的症状严重程度:一项随机对照试验
Aleksandra Kovaleva1, Elena Poluektova1,2, Roman Maslennikov1,2
1Department of Introduction to Internal Diseases, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya Str., 1, Bld. 1, 119435 Moscow, Russia.
Journal of clinical medicine
|September 28, 2023
概括
在患有腹占主导地位的刺激性肠综合征重叠功能性消化不良症 (D-IBSoFD) 的患者中,雷巴米皮德有效降低了消化症状,并改善了肠道屏障功能. 它的益处与trimebutine可比.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 功能性消化系统疾病往往表现出有限的治疗疗效.
- 对于诸如刺激性肠综合征重叠功能性消化不良症 (D-IBSoFD) 等疾病,需要新的治疗点和药物.
研究的目的:
- 评估rebamipide对D-IBSoFD患者症状严重程度,肠道屏障完整性和肠道微生物群的影响.
- 为了比较rebamipide对trimebutine和组合治疗的疗效.
主要方法:
- 一项为期2个月的随机研究,涉及60名D-IBSoFD患者,分别被分配到trimebutine,trimebutine + rebamipide或rebamipide组.
- 评估包括症状尺度,肠道屏障标记 (血清松素,组织透) 和肠道微生物群分析 (16S rRNA测序,SCFA).
主要成果:
- 雷巴米皮德和组合疗法显著降低了十二指甲腺和西格状淋巴细胞和异osinophilic 透,与单独的trimebutine 不同.
- 在rebamipide组中,血清佐努林水平显著下降.
- 症状严重程度在所有组都得到改善,炎症减少和症状缓解之间存在特定的相关性.
结论:
- 雷巴米皮德在改善肠道屏障状态和缓解D-IBSoFD的症状方面表现出有效性.
- 在治疗D-IBSoFD时,雷巴米皮德的治疗效果与trimebutine无差.
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