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慢性脏病患者的腹手术结果
Adriana Pané1,2, Maria Claro1, Alicia Molina-Andujar3,4
1Endocrinology and Nutrition Department, Hospital Clínic de Barcelona, Villarroel 170, 08036 Barcelona, Spain.
Journal of clinical medicine
|September 28, 2023
概括
腹腔外科手术 (BS) 对于患有慢性病 (CKD) 3-4期的患者来说是安全有效的. 它可以改善减肥,并发症和功能 (eGFR),而不考虑肥胖.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 腹部外科 腹部外科
- 代谢健康 代谢健康
背景情况:
- 肥胖是慢性病 (CKD) 的重要危险因素,影响全球健康.
- 腹腔外科 (BS) 有效地管理与肥胖相关的并发症,这表明预防CKD的潜力.
- 关于非晚期CKD患者的BS益处和风险的研究有限.
研究的目的:
- 为了研究腹部外科手术的安全性和有效性,在患有CKD 3-4期的患者中.
- 在CKD患者中评估BS后的代谢和结局,无论肥胖在CKD病因学中的作用如何.
主要方法:
- 一项队列研究包括57人:19人患有CKD阶段3-4和38名肥胖对照人具有正常的功能.
- 评估体重减轻,并发症解决和估计的膜过率 (eGFR) 使用CKD-EPI公式前后BS.
- 手术后1年和5年进行了后续评估.
主要成果:
- 在CKD和BS后的对照组之间,体重减轻和并发症解决是可比的.
- 在BS后1年,功能 (eGFR) 在两组中显著改善 (CKD:+10.2 mL/min/1.73 m2,对照组:+4.0 mL/min/1.73 m2).
- 经过5年,eGFR的改善持续了5年,仍然高于CKD组的基线,即使CKD与肥胖无关.
结论:
- 腹腔外科手术对于患有CKD 3-4期的患者来说是一种安全有效的干预措施.
- 在CKD患者中,BS导致体重,代谢并发症和功能显著改善.
- 不管CKD是直接由肥胖引起的,BS对功能的益处都被观察到.
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