多囊性卵巢综合征中的肥胖和高雄性精血症:临床影响
Mardia López-Alarcón1, Víctor Saúl Vital-Reyes2, Eduardo Almeida-Gutiérrez3
1Unidad de Investigación Médica en Nutrición, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Ciudad de México 06270, Mexico.
Journal of personalized medicine
|September 28, 2023
概括
代谢障碍在患有多囊性卵巢综合征 (PCOS) 的女性中很常见,肥胖症的风险高于高雄激素血症. 治疗应解决肥胖症,并监测那些有葡萄糖或肝脏问题的人的高雄素血症.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 妇女健康 妇女健康
背景情况:
- 多囊性卵巢综合征 (PCOS) 经常涉及与雄激素过量和肥胖有关的代谢障碍.
- 过高雄激素血症和肥胖对PCOS中这些代谢问题的明显贡献还没有得到很好的定义.
- 在PCOS患者的代谢变化往往被忽视.
研究的目的:
- 调查高雄激素血症 (HA) 和肥胖 (OB) 对患有PCOS的女性代谢障碍的独立和联合影响.
- 评估PCOS和没有PCOS的女性代谢变化的患病率.
- 在PCOS群体中确定受HA和OB影响的特定代谢生物标志物.
主要方法:
- 评估了99名患有PCOS的妇女和41名对照.
- 测量了葡萄糖,肝脏和内皮细胞代谢的临床生物标志物.
- 参与者被分为四组:健康 (没有HA,瘦),HA (HA,瘦),OB (没有HA,OB) 和HAOB (HA,OB).
主要成果:
- 在患有PCOS的女性中,代谢障碍的患病率很高 (约70%).
- 身体质量指数 (BMI) 与所有测量生物标志物相关;自由 (FT) 仅与葡萄糖和肝脏指标相关.
- 肥胖独立地增加了代谢障碍的风险,与瘦身相比,不论是超质. 肥胖女性的葡萄糖处置 (M较低) 和肝酶 (AST) 比瘦女性具有相似的FT水平更差.
结论:
- 肥胖是PCOS女性代谢障碍的重要独立风险因素.
- 临床医生必须对所有患有PCOS的女性进行代谢变化的查.
- 治疗策略应优先考虑肥胖管理,并考虑在患有葡萄糖或肝脏相关障碍的患者中监测高雄素血症.
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