认知功能障碍与炎症标志物和精神分裂症中心动脉内脏介质厚度之间的关系
Okan İmre1, Cuneyt Caglayan2, Mehmet Muştu3
1Department of Psychiatry, Faculty of Medicine, Karamanoglu Mehmetbey University, Karaman 70200, Turkey.
Journal of personalized medicine
|September 28, 2023
概括
精神分裂症的认知障碍与炎症增加和心动脉内心介质厚度 (CIMT) 有关. 这项研究表明,向动脉样硬化可能有助于治疗精神分裂症患者的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
背景情况:
- 精神分裂症影响全球人口的1%,导致慢性精神残疾.
- 在精神分裂症患者中,认知功能障碍和心血管风险很常见.
- 炎症和动脉样硬化可能在精神分裂症的病理生理学中起作用.
研究的目的:
- 调查认知障碍和炎症标志物之间的关系.
- 检查精神分裂症中认知功能和大脑动脉内膜介质厚度 (CIMT) 之间的关联.
- 探索炎症,CIMT和精神分裂症认知缺陷之间的联系.
主要方法:
- 对比51名精神分裂症患者与57名健康对照 (HC).
- 使用蒙特利尔认知评估 (MoCA) 尺度评估认知功能.
- 测量了炎症标志物 (NLR,MLR,PLR,SII,CRP,ESR) 和CIMT. 这些标志物包括:
主要成果:
- 与HC相比,精神分裂症患者的MoCA得分较低,NLR,MLR,PLR,SII,CRP,ESR和CIMT的水平较高 (p < 0.001).与HC相比,精神分裂症患者的MoCA得分较低,NLR,MLR,PLR,SII,CRP,ESR和CIMT的水平较高 (p < 0.001).
- 在精神分裂症患者的MoCA得分和炎症标志物之间没有发现相关性.
- 在MoCA得分和CIMT (p < 0.001) 之间观察到显著的负相关性.
结论:
- 在精神分裂症中炎症标志物和CIMT的升高表明正在进行的炎症和动脉样硬化过程.
- 这项研究是第一个证明认知障碍与精神分裂症中CIMT之间的联系的研究.
- 针对动脉样硬化过程可能是精神分裂症认知障碍的新治疗策略.
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