在长期COVID中持续的内皮肺损伤和受损的扩散能力
Andreas T Asimakos1, Alice G Vassiliou1, Chrysi Keskinidou1
1First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 106 76 Athens, Greece.
Journal of personalized medicine
|September 28, 2023
概括
长期COVID患者的内皮功能障碍标志物升高,影响肺功能和身体能力. 像sICAM-1和sVCAM-1这样的可溶性粘附分子与减少的肺扩散和运动耐受性相关.
科学领域:
- 心血管生物学 心血管生物学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID是一种SARS-CoV-2感染后的持续性疾病,呈现出各种症状.
- 内皮细胞激活和功能障碍与COVID-19的严重程度和死亡率有关.
- 内皮细胞生物标志物在长期COVID后续中的作用需要进一步调查.
研究的目的:
- 调查内皮细胞激活/功能障碍生物标志物与长期COVID综合征之间的关联.
- 探索长期COVID患者内皮标记和功能能力之间的关系.
主要方法:
- 观察性研究包括68名长期COVID患者和一个健康的对照组.
- 在两组中测量了13个内皮细胞生物标志物.
- 在长期COVID患者中评估疲劳,喘息,肺扩散能力 (DLCO) 和6分钟步行测试 (6MWT).
主要成果:
- 与对照组相比,长期COVID患者表现出更高水平的内皮激活/功能障碍标志物.
- 可溶性细胞内粘附分子1 (sICAM-1) 和可溶性血管粘附分子1 (sVCAM-1) 与DLCO和6MWT显著负相关.
- sVCAM-1与6MWT显示出强烈的负相关性 (r = -0.504,p < 0.0001).
结论:
- 内皮细胞激活/功能障碍在长期COVID的病理生理学中起作用.
- 内皮细胞生物标志物,特别是sICAM-1和sVCAM-1,可以作为长期COVID中肺部和功能能力受损的指标.
- 将内皮细胞生物标志物评估与临床测试相结合,可以提高对长期COVID机制的理解.
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