系统采样在钻井磁共振成像指导前列腺活检中的附加值
Alon Lazarovich1,2, Tomer Drori1,2, Dorit E Zilberman1,2
1Department of Urology, Chaim Sheba Medical Center, Ramat Gan 5266202, Israel.
Journal of personalized medicine
|September 28, 2023
概括
在孔内MR导向前列腺活检 (IBMRGpB) 期间的系统活检 (SB) 改善了前列腺癌的检测. 外围区域病变是临床重要疾病的关键预测因素,有助于个性化患者管理.
科学领域:
- 尿道瘤学 尿道瘤学
- 诊断成像 诊断成像 诊断成像
- 病理学 病理学 病理学
背景情况:
- 前列腺癌的诊断依赖于准确的活检技术.
- 内腔MRI导向前列腺活检 (IBMRGpB) 提供了针对性的病变可视化.
- 系统活检 (SB) 与 IBMRGpB 结合的作用需要进一步量化.
研究的目的:
- 为量化系统活检 (SB) 在内腔MR导向前列腺活检 (IBMRGpB) 中的附加诊断值.
- 用SB.确定临床上显著的前列腺癌检测的预测因子.
- 评估SB对前列腺癌整体诊断的影响.
主要方法:
- 对189名因怀疑或监测前列腺癌而接受IBMRGpB的患者的回顾性审查.
- 对癌症诊断终点的分析:临床显著性和非临床显著性疾病.
- 多变量分析以评估SB检测到临床重要疾病的预测因素.
主要成果:
- 在35.5%的患者中,SB检测到具有临床意义的疾病.
- 五名患者 (2.65%) 最初是良性或非临床显著的向活检被诊断出具有临床意义的疾病通过SB.
- 主病变的外围区域位置是SB检测到的临床重要疾病的显著预测指标 (OR=8.26,p=0.04).
结论:
- 系统活检显著增加了诊断显著和非临床显著的前列腺癌的检测率在IBMRGpB.
- 主要病变在外围区域的位置是通过SB.S.识别出临床意义疾病的强有力的积极预测指标.
- 将SB集成到IBMRGpB协议中可以提高诊断准确性并支持量身定制的患者管理策略.
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