双杆菌在COVID-19中的作用:系统性审查
Clarissa Reginato Taufer1, Pabulo Henrique Rampelotto2,3
1Graduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil.
Life (Basel, Switzerland)
|September 28, 2023
概括
肠道微生物Bifidobacterium显示了与COVID-19的复杂关系. 使用Bifidobacterium的益生菌可能有助于减轻症状,改善肺功能,并降低COVID-19患者的炎症.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行,呈现出呼吸道和肠道症状,并改变了患者的肠道微生物群.
- 生物菌 (Bifidobacterium) 属在COVID-19病变发生中的作用及其治疗潜力仍然是积极调查的领域.
研究的目的:
- 系统地审查和评估细菌属Bifidobacterium和COVID-19之间的关系.
- 评估Bifidobacterium作为治疗COVID-19症状和结果的益生菌干预剂的疗效.
主要方法:
- 在主要数据库中使用与Bifidobacterium和COVID-19/SARS-CoV-2相关的关键词进行了系统的文献搜索.
- 分析包括25篇选定的文章:18项观察性研究和7项针对Bifidobacterium益生菌的干预性研究.
- 研究涵盖了各种COVID-19阶段,严重程度和COVID-19后的情况.
主要成果:
- 双杆菌与COVID-19呈现双重关联,显示出保护作用和减少丰度,在某些情况下,丰度增加与疾病严重程度有关.
- 干预性研究表明,Bifidobacterium益生菌可以减少COVID-19症状,增强肺功能,减少炎症标志物,并缓解胃肠道问题.
- 用Bifidobacterium的益生菌与改善COVID-19患者的死亡率控制有关.
结论:
- 双杆菌在COVID-19中发挥着多方面的作用,影响疾病的进展和患者的结果.
- 肠道微生物群的调节,特别是通过Bifidobacterium补充剂,显示了COVID-19管理的重大治疗潜力.
- 双杆菌可能通过调节免疫反应,减少炎症,抑制病原体和保持肠道屏障完整性来保护COVID-19.
相关概念视频
01:29Pneumonia II: Pathophysiology
314
The pathophysiology of pneumonia involves the following steps:
314
01:26Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
01:27Bacterial Phylum Firmicutes
38
Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...
38
01:29Bacterial Flora of the Large Intestine
500
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
500
01:10Intracellular Movement of Viruses and Bacteria
2.9K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.9K
01:29Biofilms
46
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
46